A group of scientists in Australia have discovered a new potential treatment for mesothelioma cancer victims with the application of two treatments normally reserved for skin cancer patients.During several tests conducted on laboratory mice with advanced mesothelioma tumors, a skin cancer cream known as Imiquimod was combined with an anti-cancer drug, antiCD40. The two were applied to the mesothelioma mice and, according to researchers, 50 percent of the mice receiving the treatment therapy went into remission following treatment.

The study, conducted by researchers from the Sir Charles Gairdner Hospital in Australia, is considered “breakthrough” according to a PerthNow news article. Additionally, scientists feel that this potentially new mesothelioma treatment may be more readily available than other treatments being researched and tested, as one of the drugs is “already commercially available and the other is currently being tested in clinical trials,” according to lead researchers of the study.

Mesothelioma Defined

Mesothelioma is a cancer that affects thousands of individuals worldwide. It has largely been classified as a relatively rare condition, although many physicians and scientists predict a large increase of victims in the near future because of the dormant nature of the cancer. Mesothelioma cancer is caused by exposure to varied levels of asbestos fibers and dust.

During the early part of the 20th century asbestos, which derives from vermiculite, was mined and used in a plethora of products and much more heavily within the construction industry leading to the diagnosis of many construction-related workers.

Mesothelioma cancer commonly remains dormant for 10 to 30 years until symptoms begin to appear, at which point, treatment is almost non-existent.

Patients of mesothelioma cancer are advised to speak with a medical professional immediately and those who suspect they may suffer from asbestos-related conditions can also suggested to contact a medical professional and experienced mesothelioma attorney for additional information.

Diagnosing Mesothelioma

Mesothelioma is a growing condition in not only America, but around the world. A mesothelioma diagnosis is often a grim and bitter situation for not only a victim, but for family members and friends.

Once an individual has been informed of their condition, they will need to take immediate steps to ensure the best quality of care is received. By determining this, an individual increases their chances of receiving monetary compensation for their disease through the development of a mesothelioma lawsuit.

Such compensation can assist a victim with paying for costly medical treatments including chemotherapy treatments, which can range in the thousands. Speaking with a knowledgeable mesothelioma lawyer can provide insightful information as to a potential lawsuit.

Mesothelioma is cancer that affects the mesothelium which is the lining or membrane that protects and covers most of the internal organs in the body cavity. The first layer encircles the organ and the second layer forms a sac for protection. There is a lubricating fluid present between the layers to facilitate movement. The mesothelium is called pericardium when it covers the heart, pleura when covering the lungs and peritoneum when covering the abdominal organs.In mesothelioma there is uncontrolled cell division which leads to the extra cell masses invading the nearby tissues and organs and causing damage. Mostly it is observed that mesothelioma begins in the pleura or the peritoneum. The cancer then metastasizes to other parts of the body.

Mesothelioma occurs mostly due to exposure to asbestos. This is considered to be the major risk factor. 70% to 80% of sufferers have a history of exposure to asbestos. There are exceptions to this and cases have been reported where asbestos exposure was found not to exist. The condition is more common in men as compared to women. It has also been found that risk increases with age.

Mesothelioma is a very rare. Mostly said to be associated with workplace exposure to asbestos. Asbestos is a collection of minerals that can be made to exist as strong masses of sheets or flexible fibers. It is widely used in industrial products like cement, roofs, flooring products, textiles, brake linings and insulation. Tiny particles of asbestos float in the air and can be inhaled or swallowed by the people exposed to it like the workers in manufacturing companies etc.

Continuous exposure over a period can lead to asbestosis. Exposure to asbestosis increases the risk of developing mesothelioma and other types of cancer like that of kidney and larynx. There are acceptable levels of asbestos exposure that have been brought into effect in workplaces using the mineral. Another very interesting aspect of mesothelioma is that family members of people exposed asbestos in their work place show an increased incidence of this cancer as compared to others. This has been attributed to the fact that the remnants of asbestos particles adhering to the clothes, hair etc when brought home can expose the family members to it.

The cancer takes around thirty to forty years to surface. The initial symptoms include shortness of breath, and pain in the chest if it is the pleura that are affected. If the cancer is in the peritoneum then there is weight loss, abdominal swelling and pain, fluid accumulation in the abdomen, bowel obstruction. Fever, anemia and blood clotting irregularities have also been observed. In severe cases there is swelling of the neck and face, trouble swallowing and severe pain.

Diagnosis of mesothelioma is very difficult since there are no specific symptoms. A medical history review would be very valuable since asbestos exposure needs to be determined. X rays of chest, abdomen, lung function tests, scans, MRI are the usual tools that help in confirming the diagnosis. Biopsy is done for the final confirmation and treatment includes chemotherapy and radiations.

To Your Health!

DefinitionThe most thorough definition of mesothelioma describes it as a rare cancer caused by asbestos fibers that have been lodged in the mesothelium for many years. The mesothelium is the membrane that encases organs such as the lung, the heart and those of the abdomen. Although it takes many years, these fibers can cause cancer cells to grow in the membrane tissue surrounding the fibers.

Mesothelioma most often develops in the membrane surrounding the lung, and results from inhaled asbestos fibers. This mesothelial membrane is called the pleura. Because lung tissue is so soft and porous, the motion of breathing massages the fibers through the lung tissue to the membrane. The consistency of the membrane is such that the fibers penetrate the pleura and remain trapped there.

Occasionally, fibers that are swallowed follow a similar path through the stomach wall where they become lodged in the lining around the stomach, called the peritoneum. With less frequency, fibers can pass through to the lining around the heart, called the pericardium. Mesothelioma can grow in any of these membranes.

Symptoms

Pleural mesothelioma symptoms can include thickening of the pleura, pleural effusion (fluid collecting in the pleural space), which in turn compresses the lung in that area reducing the amount of oxygen that can get into the blood. This causes shortness of breath along with some pain due to inflammation and, sometimes, infection. Persistent cough is common.

Symptoms of peritoneal mesothelioma might include stomach pain or swelling, bowel obstruction, foot swelling, nausea, weight loss, and pain.

Fever, night sweats, or anemia might also be symptoms of either form of mesothelioma. Diagnosis involves specific testing to differentiate it from other diseases, many of which have similar symptoms.

Diagnosis

There are a number of diagnostic tests that are used together with the results of a physical exam to make a diagnosis of mesothelioma. These tests differentiate between diseases and allow the doctor to rule out other diseases and cancers, identifying mesothelioma as the one that matches all of the diagnostic criteria. These include:

• X-rays - X-rays can reveal pleural effusion, pleural calcification, and scarring
• CT or CAT Scan (Computed Axial Tomography) - CT Scans identify tissue density and can identify pleural effusion, pleural thickening and calcification, but it can’t differentiate between mesothelioma and other disease.
• MRI (Magnetic Resonance Imaging) - An MRI is more sensitive than CT or X-ray, and is useful for more accurate identification of tissue changes during the course of treatment, and evaluating for surgery.
• PET Scan (Positron Emission Tomography) - PET Scans measure cellular activity. Cancer cells are more active than healthy cells, and this activity shows up in PET Scans.
• Biopsy - A biopsy involves taking a sample of the suspect tissue, either with a needle or through a small incision, and sent to the lab for analysis.
• PFT (Pulmonary Function Testing) - PFT involves a set of breathing tests to measure your lung volume, elasticity, airflow, and gas exchange into your bloodstream. These measurements reveal whether areas of your lung have a reduced volume or are not exchanging gas (i.e., from pleural effusion and resulting atelectasis, aka collapsed lung,) restrictive lung disease, or reduced airflow from obstructive lung disease.
• CBC (Complete Blood Count) - CBC shows the number of red and white blood cells and platelets, the amount of hemoglobin, and the percent of blood that is red blood cells. It also tests other common blood factors that indicate health and illness.
• Bronchoscopy - A bronchoscope is inserted into the patient’s lungs through the throat that allows the doctor to view the trachea and upper airways. The scope has the ability to take a tissue sample that can be examined under a microscope, in the same was as tissue collected from a biopsy.
• Cytology - A pathologist microscopically examines cells drawn from fluid near the site of the suspected disease.

The U.S. Department of Labor gives links to OSHA’s standards and guidelines for evaluating exposure to asbestos. These links include medical questionnaires, X-ray interpretation standards, medical surveillance for asbestos and more.

If you work with or around asbestos and aren’t properly protected, there is a chance that prolonged exposure will leave you vulnerable to developing mesothelioma. Mesothelioma is a form of cancer that is caused by exposure to asbestos. With mesothelioma, malignant cells grow in the mesothelium, which is the protective lining that covers many of the body’s most important internal organs. The most common place for this cancer to develop in on the lining of the lungs or on the chest wall, although it can develop elsewhere within the body. Because mesothelioma can be prevented by safety equipment and because it is a work-related illness, compensation claims are a big issue.The first claim against an asbestos manufacturer was in 1929, although as part of the lawsuit it was agreed to not pursue any further cases. It wasn’t until the 1960’s that asbestos was officially recognised as the cause of mesothelioma. An article was written in which more than 30 cases of people working with asbestos and suffering from the disease were recorded. Today, many claims are made by employees against employers who have failed to implement strict safety measures, rendering the employer negligent. In the US claims resulting from asbestos lawsuits have now reached into billions of dollars. In the UK claims are less common but the number of lawsuits citing asbestos as the primary cause of mesothelioma is growing steadily.

On the 20 August 2008 Thomas Renfrew of Ardrossan, Ayrshire, was awarded £130,000 in damages for ill health due to exposure to asbestos. He worked as a shipbuilder for 14 years, often coming into contact with asbestos. It was argued in court that Mr Renfrew could live for another 10 years with the disease and that the amount of money rewarded was to make the rest of his life a more pleasant one. The companies that he worked for wanted to pay significantly less because they estimated that he would only live for another 3 years, effectively admitting that his exposure to asbestos had affected his health and predicted life span.

Today, an increasing number of claims are being made due to mesothelioma. One of the reasons for this may be that the symptoms often don’t appear until 20 to 50 years after the asbestos exposure. Symptoms include shortness of breath, persistent coughing, chest pains, weight loss, abdominal swelling and a wide range of other problems. In the later stages of the disease tumours develop throughout the body, although usually these tumours are located primarily in the lungs. As the symptoms of mesothelioma are similar to other illnesses, they can often be misdiagnosed. Obviously, as you can see in the case of Mr Renfrew, life expectancy is reduced dramatically.

If you have worked with asbestos in the past and you experience any of these symptoms then you should consult a doctor immediately. You may also wish to contact specialist claims lawyer who has experience with asbestos cases. As you can see from the Renfrew case, claims of asbestos poisoning and the contraction of mesothelioma are taken very seriously indeed. It is important to have a specialist lawyer working for you, as they will understand the legal proceedings that will directly apply to a claim of this nature. They will also be aware of past cases that can have a bearing on your own case.

Mesothelioma is one of the most uncommon types of cancer and is almost always caused by past exposure to asbestos. It is believed to affect around 2000 people in the UK each year. There are two different forms of mesothelioma; pleural mesothelioma (which makes the lining of the lungs become thicker) and peritoneal mesothelioma (which makes the lining of the abdomen become thicker). Being diagnosed with this type of cancer is not a pleasant experience. However, there are treatment options available. In this article I will be explaining three of the top mesothelioma treatments.1) SURGERY:- If you have pleural mesothelioma and it is in the early stages, surgery may be a viable treatment option. However, it cannot usually be used to treat peritoneal mesothelioma. When surgery is possible it will usually involve a pleurectomy (removing part or all of the pleura and the surrounding lung tissue) but sometimes an extra-pleural pneumonectomy (removing the pleura, the diaphragm, the tumour and the whole lung) is required for more advanced cancers.

2) CHEMOTHERAPY:- This mesothelioma treatment involves using anti-cancer medications to slow the growth of the tumour. It can also help reduce any undesirable symptoms. Unfortunately, in most cases chemotherapy alone is not enough to cure mesothelioma and instead helps provide sufferers with a better quality of life. However, it can be effective after surgery for killing off any remaining cancer cells and reducing the risk of recurrence.

Chemotherapy treatment does come with some undesirable side effects. The main side effect is that the drugs used often kill some non-cancerous cells too which makes you more susceptible to infections and can make you tire more easily. There are other associated side effects which include hair loss, nausea and diarrhoea. However, these depend upon the type of chemotherapy drug being used.

3) RADIOTHERAPY:- This involves using high energy radiation beams to destroy the cancerous cells. Radiotherapy is often used to relieve any undesirable symptoms but can sometimes prove an effective treatment for mesothelioma. It can also be used to shrink the tumour before surgery and to reduce the risk of the cancer returning after surgery.

Radiotherapy treatment also has comes with some unwanted side effects. These include nausea, vomiting and tiredness. However, these side effects and their severity varies depending upon the strength of the radiation used and the length of the radiotherapy treatment.

Mesothelioma is very rare but like any other cancer it can prove fatal if ignored. No one wants to be diagnosed with a condition like this but it can be treated. This article has discussed three of the options that are available but to get the full picture you need to go see your doctor. They are the professionals and they will be able to choose the best type of treatment for you and your circumstances.

Whilst every intention has been made to make this article accurate and informative, it is intended for general information only. Mesothelioma is a very serious, life threatening condition and you should discuss any concerns, treatments or lifestyle changes fully with your doctor.