DefinitionThe most thorough definition of mesothelioma describes it as a rare cancer caused by asbestos fibers that have been lodged in the mesothelium for many years. The mesothelium is the membrane that encases organs such as the lung, the heart and those of the abdomen. Although it takes many years, these fibers can cause cancer cells to grow in the membrane tissue surrounding the fibers.

Mesothelioma most often develops in the membrane surrounding the lung, and results from inhaled asbestos fibers. This mesothelial membrane is called the pleura. Because lung tissue is so soft and porous, the motion of breathing massages the fibers through the lung tissue to the membrane. The consistency of the membrane is such that the fibers penetrate the pleura and remain trapped there.

Occasionally, fibers that are swallowed follow a similar path through the stomach wall where they become lodged in the lining around the stomach, called the peritoneum. With less frequency, fibers can pass through to the lining around the heart, called the pericardium. Mesothelioma can grow in any of these membranes.

Symptoms

Pleural mesothelioma symptoms can include thickening of the pleura, pleural effusion (fluid collecting in the pleural space), which in turn compresses the lung in that area reducing the amount of oxygen that can get into the blood. This causes shortness of breath along with some pain due to inflammation and, sometimes, infection. Persistent cough is common.

Symptoms of peritoneal mesothelioma might include stomach pain or swelling, bowel obstruction, foot swelling, nausea, weight loss, and pain.

Fever, night sweats, or anemia might also be symptoms of either form of mesothelioma. Diagnosis involves specific testing to differentiate it from other diseases, many of which have similar symptoms.

Diagnosis

There are a number of diagnostic tests that are used together with the results of a physical exam to make a diagnosis of mesothelioma. These tests differentiate between diseases and allow the doctor to rule out other diseases and cancers, identifying mesothelioma as the one that matches all of the diagnostic criteria. These include:

• X-rays - X-rays can reveal pleural effusion, pleural calcification, and scarring
• CT or CAT Scan (Computed Axial Tomography) - CT Scans identify tissue density and can identify pleural effusion, pleural thickening and calcification, but it can’t differentiate between mesothelioma and other disease.
• MRI (Magnetic Resonance Imaging) - An MRI is more sensitive than CT or X-ray, and is useful for more accurate identification of tissue changes during the course of treatment, and evaluating for surgery.
• PET Scan (Positron Emission Tomography) - PET Scans measure cellular activity. Cancer cells are more active than healthy cells, and this activity shows up in PET Scans.
• Biopsy - A biopsy involves taking a sample of the suspect tissue, either with a needle or through a small incision, and sent to the lab for analysis.
• PFT (Pulmonary Function Testing) - PFT involves a set of breathing tests to measure your lung volume, elasticity, airflow, and gas exchange into your bloodstream. These measurements reveal whether areas of your lung have a reduced volume or are not exchanging gas (i.e., from pleural effusion and resulting atelectasis, aka collapsed lung,) restrictive lung disease, or reduced airflow from obstructive lung disease.
• CBC (Complete Blood Count) - CBC shows the number of red and white blood cells and platelets, the amount of hemoglobin, and the percent of blood that is red blood cells. It also tests other common blood factors that indicate health and illness.
• Bronchoscopy - A bronchoscope is inserted into the patient’s lungs through the throat that allows the doctor to view the trachea and upper airways. The scope has the ability to take a tissue sample that can be examined under a microscope, in the same was as tissue collected from a biopsy.
• Cytology - A pathologist microscopically examines cells drawn from fluid near the site of the suspected disease.

The U.S. Department of Labor gives links to OSHA’s standards and guidelines for evaluating exposure to asbestos. These links include medical questionnaires, X-ray interpretation standards, medical surveillance for asbestos and more.

Pleural mesothelioma diagnosis is typically met with the striking news that a patient has less than a year or two to live. Early diagnosis of pleural mesothelioma can increase the likelihood of effective treatment. Identifying a level of protein from a specific gene might just be the key to early mesothelioma treatment.Pleural mesothelioma is significantly more alarming than other asbestos-caused diseases such as asbestosis because of the high risk of death that comes along with the diagnosis of this cancer. However, the short life span that follows mesothelioma is often a result of its late diagnosis. If this asbestos caused cancer were to be diagnosed earlier, then potentially life-saving treatment could begin earlier.

Pleural mesothelioma and asbestosis are lung diseases that produce symptoms similar to hundreds of other potential respiratory illnesses and cancers. Although a history of working with asbestos is a strong indicator that asbestos may be the cause of a patient’s lung disease, many patients fail to mention their working history to their physicians, and many physicians dismiss the possibility of asbestos related disease because of its low reported statistics. These statistics, however, are vastly under-reported, as many countries do not have the access to the medical knowledge, equipment, or personnel to correctly determine and report asbestos-caused diseases. Asbestos use continues to thrive around the world, and the incidences of asbestos caused cancer and asbestosis will continue to thrive as well.

Medial researchers are trying to prepare for the future epidemic of asbestos illnesses that the asbestos workers of today will be suffering from in the upcoming decades. Although a cure for pleural mesothelioma is far off in the distance, medical researchers have found that a protein gene identified as osteoprontin exists in patients with this disease and their serum osteoprontin levels are six times higher than other lung disease patients. Osteoprontin is typically associated with the bones since it is a protein located in the bones. However, the gene is an active participant and an important player in bone remodeling, wound healing, and the immune system. The University of Bristol in the UK also found that the gene needs to be suppressed to prevent dangerous scarring of internal tissues and have begun to work on a gel to speed up wound healing that facilitates this suppression.

For patients suffering from undiagnosed respiratory illnesses, identifying an increase in serum osteoprontin can distinguish asbestos cancer from asbestosis or lung cancer. This will save years of unnecessary testing and expenses, provide the opportunity for early cancer treatment, and even increase the swiftness of processing asbestos workers’ compensation claims.

Pleural mesothelioma research, medical research on asbestosis, and medical research on other asbestos-related diseases continues to contribute valuable findings that can contribute to improving care and provide valuable medical insights that can be applied within multiple medical fields. Soluble mesothelin-related peptide is similar to osteoprontin, and is also a unique identifier of mesothelioma. Accessible medical access that can test individuals for both of these unique markers can have a significant impact on the health and longevity of today’s asbestos workers. Lung diseases may soon be more easily differentiated. But that isn’t enough. Medical accessibility must be improved around the world so today’s asbestos workers can get the early treatment they need to survive.

Medical records that pertain to asbestosis or mesothelioma must be dug up from the archives of the past. Without medical record collections and retrievals, the forewarnings of impending asbestosis and mesothelioma come only from witnessing the sufferings of an asbestosis patient or the languishing death of a mesothelioma cancer patient.Asbestosis and mesothelioma statistics are sharply under-estimated due to the lack of many nations to implement an efficient medical retrieval system and properly care for and diagnose lung disease patients who are suffering from asbestosis or mesothelioma due to asbestos exposure. In many nations, physicians that are able to properly diagnose the disease are rarely, if ever, available. These same nations often have poor record keeping systems in place to monitor health trends and examine medical histories. Many times asbestosis and mesothelioma are simply referenced as “lung disease,” without a proper determination of the classification of lung disease.

Years pass before these progressive lung diseases start showing their scarring presence, but an archive of medical history can facilitate proper diagnosis, and national archives of medical histories can facilitate early warnings. Despite this knowledge, India has no cancer registry, nor does it have a system for recording mesothelioma and asbestosis cases. In the Philippines, the Occupational Safety and Health Center (OSHC) reports that asbestos caused diseases will be under diagnosed due to low employer participation in submitting medical records to a central agency. (Less than 5% of employers do so.)

In Brazil, where corporations scurry to cover any implications of occupational hazards or ill will, medical records are virtually non-existent for asbestos workers. The Eternit asbestos plant in Brazil has had asbestos workers for over 50 years, yet no medical records were ever kept prior to 1978. In China, death records are purged and permanently eliminated after death, leaving no source for documenting trends in deaths or comparisons and similarities between diseases. And although China is one of the top five asbestos producers and users in the world, this nation continues to have a minimal amount of empirical studies on the implications of asbestos exposure.

Fortunately, in many nations, allowable exposure limits are being reduced, inspections are being heightened, and politicians and corporations are being pressured. Environmental groups and protection agencies continue to test asbestos material and promote its eventual ban. Unfortunately, politics and corporations still govern irresponsible asbestos promotions, and millions of innocent people are unaware of its dangers. The lack of public awareness has led to a deadly economic dependency on asbestos.

Asbestosis and mesothelioma deaths need to be recorded, death records need to be maintained, and medical histories of asbestos workers need to be compiled to gain a full realization of the statistical and economical impact of the world’s burgeoning asbestosis and mesothelioma crisis. Asbestosis and mesothelioma records are useless, however, unless they are used to promote change and develop public awareness - which is precisely what the mining and trading nations are afraid of.

The lung diseases asbestosis and mesothelioma have been proven for decades to be a result of asbestos exposure. Yet, asbestos continues to be mined, and employers still fail to protect workers from the dangers of asbestos. Faint warnings to the public have been made barely audible, and a deadly global health epidemic is looming on the horizon.Asbestosis and mesothelioma are the subjects of 21st century international reports warning international officials, advocacy workers, and the general public of an impending epidemic of these two devastating diseases. Asbestosis and mesothelioma, which are caused by exposure to asbestos, take decades to surface symptoms, and the retired workers of yesteryear’s thriving asbestos industries are beginning to suffer from asbestos related diseases today.

In countries like Brazil, workers suffered decades under corrupt politics, medical care was discouraged, workers were randomly dismissed from employment, and diagnostic tests were not made available to support any identification or claim for asbestosis or mesothelioma. It is only recently that unions protecting workers have surfaced, but for thousands of asbestos workers, it is too late to avoid succumbing to the harsh lung disease of asbestosis or the fatal cancer of mesothelioma.

As workers and innocent home dwellers continue to be exposed to asbestos, the death estimates due to asbestos related diseases will continue to reach into the next half century. Factories in China spew asbestos from their factories into neighboring cities. In Africa, a state of emergency has been requested in asbestos filled territories where hundred-mile stretches are filled with residents living, working and sleeping while surrounded by airborne asbestos fibers. In India, the European Asbestos Removal Association (EARA) issued a 2008 report titled “India’s Asbestos Time Bomb” which warns of India’s future burden of caring for tens of thousands of asbestosis and mesothelioma patients as a result of India’s infatuation with asbestos products. In this asbestos removal report, comparisons are made between the export levels of India and the UK. In just two decades, India’s asbestos imports surpassed the levels that the UK used in their entire industrial history. The UK is now facing record levels of occupational disease, with thousands dying from mesothelioma every year. Despite the UK’s forewarning of the future, India continues to import massive tons of asbestos products annually, and corporations with significant monetary interest encourage unsuspecting consumers to embrace the use of asbestos products.

Even with indiscriminate medical records that deflate the actual deaths due to asbestosis and mesothelioma, the World Health Organization estimates that asbestosis and mesothelioma will be responsible for 90,000 deaths around the world in a single year. As long as asbestos continues to be mined, imported and exported - the numbers will continue to rise over the next century.

Asbestosis and mesothelioma are not diseases that are easily recognized by physicians or the lay citizen. The public must be made aware of the dangers of working with, and living with, asbestos made products. Scientists and manufacturers must race to discover the economic answer to replace asbestos products with a safer alternative. But with or without change, the next decade will surface the consequences of haphazard occupational healthcare as the children of tomorrow care for the asbestos workers of today

Mesothelioma is a type of cancer that affects the lining of the lungs and the abdomen. It is one of the less common types of cancer affecting approximately 2000 people each year in the UK and it is almost always caused by asbestos exposure. If it affects the lining of the lungs (the pleura) it is referred to as pleural mesothelioma. In this article I will be outlining three of the most common symptoms for this type of cancer and explaining what you should do if you suspect you have developed this condition.The pleura (lining of the lungs) is actually comprised of two parts. It has an inner (visceral) layer which is next to the lung and an outer (parietal) layer that covers the chest wall. The two layers slide over each other as we breath and membranes in the lungs often produce lubricating fluid to make this process easier. When pleural mesothelioma develops it causes the inner and outer layers to become thicker and they then press inwards on the lungs. This can lead to a number of undesirable symptoms which I will discuss below:

1) DIFFICULTY BREATHING:- As the inner and outer layers of the pleura start to push against the lungs it may become difficult for you to breathe. This can then lead to your throat becoming hoarse, coughing, problems swallowing and regular feelings of being out of breath.

2) PAIN IN THE CHEST:- As the layers of the pleura push against the lungs this can cause chest pain. You may also feel pain in your shoulders and arms.

3) PLEURAL EFFUSION:- As I mentioned above the membranes of the lungs produce lubricating fluid which allows the layers of the pleura to easily slide against each other. However, when pleural mesothelioma develops the inner and outer layers become thicker and fluid can become trapped more easily. If fluid does become trapped it is referred to as pleural effusion. Pleural effusion can lead to further chest pain and difficulty breathing but often has no symptoms that you will feel.

If you notice any of the above pleural mesothelioma symptoms you should go see your doctor right away. If you have previously been exposed to asbestos then you should inform your doctor of this also. Since this type of cancer is almost always caused by asbestos exposure this information will help them make an accurate diagnosis. Once your doctor is aware of these symptoms they will be able to perform a number of tests and make the call. If their results indicate that you do have pleural mesothelioma they will then be able to suggest the best treatments for your circumstances.

Mesothelioma is a very rare type of cancer and in the majority of cases these symptoms will be down to something much less serious. However, if you notice any of these symptoms and do not go see your doctor then the condition cannot be diagnosed and treated. Even a slight chest pain or a small but small but long lasting cough are possible symptoms. If you notice any symptoms at all go see your doctor right away.

Whilst every intention has been made to make this article accurate and informative, it is intended for general information only. Mesothelioma is a very serious, life threatening condition and you should discuss any concerns, treatments or lifestyle changes fully with your doctor.